Negative regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Negative regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REXO1, CFD, and VAMP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Arp2/3 complex-mediated actin nucleation activity versus REXO1 in SKIN (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REXO1 →	+0.398	+0.535	.002	.007	3	4
BLOOD_Leukemia	CFD →	+3.254	+0.166	<.001	.002	3	4
OESOPHAGUS	VAMP1 →	-1.248	-0.236	<.001	.001	3	4
BLOOD_Leukemia	SNTB2 →	-1.013	-0.163	<.001	<.001	3	4
BLOOD_Lymphoma	GPR160 →	+2.229	+1.108	<.001	<.001	3	4
OESOPHAGUS	FSCN1 →	-3.780	-0.278	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034316 vs REXO1 — SKIN

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