Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAU, SND1, and RPL30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arp2/3 complex-mediated actin nucleation activity versus PLAU in PDAC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLAU →	-0.592	-0.022	<.001	.001	3	5
BRCA	SND1 →	-0.273	-0.026	.007	.001	3	5
GBM	RPL30 →	-0.221	-0.046	<.001	<.001	3	5
GBM	RPL5 →	-0.185	-0.046	<.001	<.001	3	5
GBM	RPS2 →	-0.191	-0.045	<.001	<.001	3	5
GBM	RPS26 →	-0.283	-0.035	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034314 vs PLAU — PDAC

Explore this scatter interactively →