Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP2, CEP57L1, and SEMA4D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP2 grouped by Arp2/3 complex-mediated actin nucleation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PARP2 →	+1.009	+1.580	<.001	<.001	3	4
SOFT_TISSUE	CEP57L1 →	+0.520	+1.356	.002	.001	3	4
SOFT_TISSUE	SEMA4D →	+0.793	+1.438	.009	.002	3	4
BREAST	TBC1D10B →	-0.657	-0.362	.002	.004	2	5
PANCREAS	H3C4 →	-0.648	-0.781	.007	.009	3	4
SKIN	MSS51 →	+0.412	+0.821	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP2 by Arp2/3 complex-mediated actin nucleation activity — KIDNEY

Explore this box plot interactively →