Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC2, ARPC4, and SLC16A3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arp2/3 complex-mediated actin nucleation activity versus ARPC2 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARPC2 →	+0.954	+0.373	<.001	.003	3	8
BLOOD_Leukemia	ARPC4 →	+0.961	+0.222	.003	.003	3	7
OVARY	SLC16A3 →	+2.852	+0.460	.008	.002	3	5
BLOOD_Lymphoma	SH3KBP1 →	+2.335	+0.184	.001	.004	3	5
SKIN	SLC25A20 →	+0.952	+0.262	.001	.002	3	5
BLOOD_Leukemia	TENT5A →	+2.365	+0.196	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034314 vs ARPC2 — STOMACH

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