Diol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2L2, CCDC200, and ANKHD1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol biosynthetic process activity versus PKD2L2 in ESCA (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	PKD2L2 →	+0.225	+0.051	<.001	<.001	3	20
KIRC	CCDC200 →	+0.669	+0.029	<.001	<.001	3	20
KICH	ANKHD1 →	+0.444	+0.025	<.001	<.001	2	20
UCS	SNORD63 →	+1.006	+0.037	<.001	<.001	3	19
ESCA	DDX50P1 →	+0.291	+0.049	.001	<.001	3	19
KIRC	CFLAR-AS1 →	+0.515	+0.028	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034312 vs PKD2L2 — ESCA

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