Diol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRNP200, UTP20, and ANXA9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol biosynthetic process activity versus SNRNP200 in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNRNP200 →	-0.226	-0.043	<.001	<.001	3	6
BRCA	UTP20 →	-0.275	-0.032	.002	.001	3	5
BRCA	ANXA9 →	+0.721	+0.038	<.001	<.001	3	5
OV	CHEK2 →	-0.551	-0.047	<.001	<.001	3	5
GBM	XPO5 →	-0.403	-0.058	.001	<.001	3	5
PDAC	TMX2 →	-0.359	-0.044	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034312 vs SNRNP200 — BRCA

Explore this scatter interactively →