Diol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS7P1, ST3GAL4, and SCN1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol biosynthetic process activity versus ADAMTS7P1 in COAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADAMTS7P1 →	-0.043	-0.125	.006	.006	3	3
GBM	ST3GAL4 →	+0.346	+0.170	.007	<.001	3	3
GBM	SCN1A →	-0.912	-0.164	.004	<.001	3	3
BRCA	WASL →	+0.641	+0.182	<.001	.003	3	3
BRCA	TRIM23 →	+0.785	+0.209	<.001	<.001	3	3
BRCA	CNTN3 →	+0.671	+0.138	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034312 vs ADAMTS7P1 — COAD

Explore this scatter interactively →