Diol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Diol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA4, UCK2, and PA2G4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASA4 grouped by Diol biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RASA4 →	-1.057	-0.953	.005	.003	2	6
UPPER_AERODIGESTIVE_TRACT	UCK2 →	-1.159	-1.484	.008	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PA2G4 →	-1.273	-1.542	<.001	<.001	3	4
BLOOD_Lymphoma	OSGEP →	-0.955	-1.678	.001	<.001	3	4
BONE	CC2D1B →	-0.996	-1.637	.003	<.001	3	4
BLOOD_Leukemia	ZNF839 →	-0.536	-1.048	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASA4 by Diol biosynthetic process activity — STOMACH

Explore this box plot interactively →