Diol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Diol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0A1, WHRN, and GSR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol biosynthetic process activity versus ATP6V0A1 in KIDNEY (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ATP6V0A1 →	+1.554	+0.311	.003	.001	3	5
BLOOD_Lymphoma	WHRN →	+2.219	+0.986	<.001	<.001	3	5
LIVER	GSR →	+1.924	+0.482	.002	<.001	3	5
BLOOD_Lymphoma	SLC26A11 →	+1.799	+0.836	<.001	<.001	3	5
BLOOD_Lymphoma	GGT1 →	+2.917	+0.844	<.001	<.001	3	4
LIVER	PPP1R37 →	+0.646	+0.320	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034312 vs ATP6V0A1 — KIDNEY

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