Diol metabolic process

Across TCGA patient cohorts, RNA activity of the Diol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF5B, BAZ1B_S349, and DDX47, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol metabolic process activity versus EIF5B in LSCC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EIF5B →	-0.220	-0.033	.002	.004	3	6
LUAD	BAZ1B_S349 →	-0.790	-0.049	.008	.009	3	6
BRCA	DDX47 →	-0.334	-0.037	<.001	<.001	3	6
LSCC	SNRNP200 →	-0.218	-0.045	.002	<.001	3	6
LSCC	XPO5 →	-0.558	-0.034	<.001	<.001	3	6
GBM	NIPSNAP3A →	+0.516	+0.048	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034311 vs EIF5B — LSCC

Explore this scatter interactively →