Diol metabolic process

Across TCGA cell cohorts, RNA activity of the Diol metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PWWP2B, CYP21A2, and ACSL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PWWP2B grouped by Diol metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PWWP2B →	-0.217	-1.596	.003	<.001	3	5
SOFT_TISSUE	CYP21A2 →	+0.180	+1.227	.005	.006	3	5
BLOOD_Myeloma	ACSL6 →	+0.297	+1.182	.003	.003	3	5
BLOOD_Myeloma	STK31 →	+0.327	+1.484	.001	<.001	3	4
BLOOD_Leukemia	SPTLC2 →	-0.133	-1.057	.005	.002	3	4
SKIN	WIF1 →	-0.156	-0.688	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PWWP2B by Diol metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →