Diol metabolic process

Across TCGA cell cohorts, RNA activity of the Diol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAP3, CLIC4, and CREB3L4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diol metabolic process activity versus PGAP3 in BREAST (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PGAP3 →	+1.995	+0.384	<.001	.005	3	6
LARGE_INTESTINE	CLIC4 →	-0.918	-0.189	.009	.003	3	6
BREAST	CREB3L4 →	+1.960	+0.446	<.001	<.001	3	5
LUNG_NSCLC_LUAD	GDF15 →	+2.971	+0.451	<.001	.003	3	5
BLOOD_Lymphoma	SUOX →	+1.666	+0.686	<.001	.004	3	4
BLOOD_Lymphoma	ZNF620 →	+0.743	+0.815	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034311 vs PGAP3 — BREAST

Explore this scatter interactively →