Primary alcohol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Primary alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, TMEM200A, and CYP7B1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary alcohol biosynthetic process activity versus DAB2 in GBM (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.993	+0.318	<.001	<.001	3	7
BRCA	TMEM200A →	+0.663	+0.636	<.001	<.001	3	6
BRCA	CYP7B1 →	+0.681	+0.770	.003	.001	3	6
LSCC	NOP56 →	-0.460	-0.797	.001	<.001	3	6
GBM	OLFML2B →	+0.825	+0.262	<.001	.005	3	6
GBM	C1S →	+0.872	+0.333	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034309 vs DAB2 — GBM

Explore this scatter interactively →