Response to disaccharide

Across TCGA patient cohorts, RNA activity of the Response to disaccharide pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD1, CAVIN2, and KBTBD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to disaccharide activity versus ADD1 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADD1 →	+0.396	+0.073	<.001	<.001	3	5
BRCA	CAVIN2 →	+0.591	+0.052	<.001	<.001	3	5
BRCA	KBTBD11 →	+0.347	+0.068	.006	.002	3	5
HNSC	RPS25 →	-0.374	-0.077	<.001	<.001	3	4
GBM	SPTBN1_S2106 →	+0.487	+0.059	.001	.004	3	4
GBM	CABLES1 →	+0.386	+0.065	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034285 vs ADD1 — GBM

Explore this scatter interactively →