Response to disaccharide

Across TCGA patient cohorts, RNA activity of the Response to disaccharide pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL6B, GOLIM4, and SH3TC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to disaccharide activity versus BCL6B in CCRCC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BCL6B →	+0.799	+0.134	.008	.007	3	5
BRCA	GOLIM4 →	+0.745	+0.371	<.001	.003	3	4
GBM	SH3TC1 →	+0.745	+0.177	<.001	.005	3	4
UCEC	DSE →	+0.283	+0.215	.009	.002	3	3
UCEC	ALOX5AP →	+0.792	+0.227	.001	<.001	3	3
UCEC	SCHIP1 →	+0.524	+0.312	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034285 vs BCL6B — CCRCC

Explore this scatter interactively →