Response to disaccharide

Across TCGA cell cohorts, RNA activity of the Response to disaccharide pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF707, GDPD3, and UBN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF707 grouped by Response to disaccharide-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF707 →	-0.178	-1.207	.008	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	GDPD3 →	-0.131	-0.135	.007	.003	3	3
BONE	UBN1 →	+0.258	+1.606	.005	.001	3	3
BLOOD_Lymphoma	SCYL3 →	+0.200	+0.285	.001	<.001	3	3
BLOOD_Myeloma	RASL11B →	+0.397	+2.133	.001	<.001	3	3
SOFT_TISSUE	ATAD5 →	+0.160	+1.165	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF707 by Response to disaccharide activity — CNS

Explore this box plot interactively →