Negative regulation of GTPase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of GTPase activity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, RPRD2_T732, and SERBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of GTPase activity activity versus HIP1 in COAD (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HIP1 →	+0.230	+0.020	.004	.006	3	7
PDAC	RPRD2_T732 →	-0.519	-0.028	<.001	<.001	3	6
COAD	SERBP1 →	-0.262	-0.026	<.001	.001	3	6
GBM	DNTTIP2 →	-0.266	-0.070	.003	<.001	3	6
COAD	ACIN1 →	-0.221	-0.036	<.001	<.001	3	6
PDAC	ERH →	-0.407	-0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034260 vs HIP1 — COAD

Explore this scatter interactively →