Negative regulation of GTPase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of GTPase activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM10L2B, SH2B1, and LRRK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of GTPase activity activity versus SMIM10L2B in GBM (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMIM10L2B →	-0.515	-0.673	.008	.006	3	4
HNSC	SH2B1 →	-0.479	-0.874	<.001	.001	3	4
LUAD	LRRK2 →	+1.199	+1.014	<.001	<.001	3	3
OV	FAM131A →	-0.515	-0.648	.009	.006	3	3
HNSC	NAA80 →	-0.402	-0.595	<.001	.002	3	3
HNSC	RBM6 →	-0.568	-0.861	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034260 vs SMIM10L2B — GBM

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