Negative regulation of GTPase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of GTPase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF610, GPATCH3, and PRPF4B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF610 grouped by Negative regulation of GTPase activity-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZNF610 →	-1.520	-1.236	<.001	.005	3	3
LUNG_SCLC	GPATCH3 →	+0.529	+0.979	<.001	.004	3	3
PANCREAS	PRPF4B →	+0.514	+0.923	.004	.003	3	3
PANCREAS	KDM3A →	+0.527	+0.900	.001	.007	3	3
PANCREAS	EAF1 →	+0.659	+1.095	.001	<.001	3	3
PANCREAS	WDR6 →	+0.694	+1.032	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF610 by Negative regulation of GTPase activity activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →