Negative regulation of syncytium formation by plasma membrane fusion

Across TCGA patient cohorts, RNA activity of the Negative regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPDH1P10, CXCL10, and CXCL11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of syncytium formation by plasma membrane fusion activity versus IMPDH1P10 in LUAD (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IMPDH1P10 →	+0.331	+0.084	.001	.005	3	4
HNSC	CXCL10 →	+2.811	+0.280	<.001	<.001	3	4
HNSC	CXCL11 →	+2.710	+0.312	<.001	<.001	3	4
UCEC	ITGA3 →	+1.136	+0.321	.007	.001	3	4
HNSC	ICAM1 →	+0.844	+0.326	.009	.005	3	4
BRCA	VPS37A →	-0.488	-0.378	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034242 vs IMPDH1P10 — LUAD

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