Negative regulation of syncytium formation by plasma membrane fusion

Across TCGA patient cohorts, RNA activity of the Negative regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAPGEF3_S528, ITFG2_S104, and GBP5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of syncytium formation by plasma membrane fusion activity versus RAPGEF3_S528 in LSCC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAPGEF3_S528 →	+0.611	+0.571	<.001	.001	3	4
LUAD	ITFG2_S104 →	+0.687	+0.178	.001	<.001	3	3
HNSC	GBP5 →	+0.962	+0.296	<.001	<.001	3	3
LSCC	SH3KBP1_S503 →	+0.681	+0.459	<.001	<.001	3	3
OV	TMEM94_S225 →	-1.551	-1.296	<.001	.002	3	3
GBM	PHRF1_S973 →	-0.397	-0.163	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034242 vs RAPGEF3_S528 — LSCC

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