Negative regulation of syncytium formation by plasma membrane fusion

Across TCGA cell cohorts, RNA activity of the Negative regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYOX1L, PYCR3, and BMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCYOX1L grouped by Negative regulation of syncytium formation by plasma membrane fusion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCYOX1L →	+0.860	+0.227	<.001	<.001	3	5
BLOOD_Myeloma	PYCR3 →	-1.371	-0.571	.002	<.001	3	4
PANCREAS	BMP2 →	+1.126	+0.187	.009	.009	3	4
BLOOD_Lymphoma	SYNGAP1 →	+1.302	+0.771	.005	.003	3	4
KIDNEY	NTM →	+1.529	+0.424	.003	.006	3	4
OESOPHAGUS	BRSK1 →	+1.838	+0.431	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCYOX1L by Negative regulation of syncytium formation by plasma membrane fusion activity — BREAST

Explore this box plot interactively →