Negative regulation of syncytium formation by plasma membrane fusion

Across TCGA cell cohorts, RNA activity of the Negative regulation of syncytium formation by plasma membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP1, COTL1, and RAB32, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of syncytium formation by plasma membrane fusion activity versus TOP1 in LUNG_NSCLC_LUAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TOP1 →	-0.593	-0.158	.004	.001	3	6
OVARY	COTL1 →	+1.439	+0.333	.006	.007	3	5
LUNG_NSCLC_LUAD	RAB32 →	+1.342	+0.159	.007	.001	3	5
STOMACH	CDR2L →	+1.354	+0.228	<.001	.003	3	5
BLOOD_Lymphoma	DOCK5 →	+2.139	+0.210	.002	.003	3	5
BLOOD_Lymphoma	FYCO1 →	+1.389	+0.192	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034242 vs TOP1 — LUNG_NSCLC_LUAD

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