Regulation of macrophage fusion

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage fusion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B1, TRRAP, and NCL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage fusion activity versus SF3B1 in GBM (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B1 →	-0.213	-0.072	.001	<.001	3	7
GBM	TRRAP →	-0.218	-0.089	.001	<.001	3	7
COAD	NCL →	-0.255	-0.051	.002	.001	3	7
LSCC	NOL11 →	-0.389	-0.102	<.001	<.001	3	7
LSCC	PDCD11 →	-0.360	-0.093	<.001	<.001	3	7
LSCC	RCL1 →	-0.265	-0.084	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034239 vs SF3B1 — GBM

Explore this scatter interactively →