Regulation of macrophage fusion

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage fusion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODR4, TPR, and TMEM80, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ODR4 grouped by Regulation of macrophage fusion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ODR4 →	+0.540	+1.098	.006	.003	3	4
LARGE_INTESTINE	TPR →	+0.650	+0.781	.003	.005	3	4
LUNG_SCLC	TMEM80 →	+1.085	+1.233	.008	.008	3	4
BLOOD_Leukemia	SLC27A3 →	+1.272	+1.087	.003	<.001	3	4
BLOOD_Myeloma	RGS1 →	+4.296	+1.466	<.001	<.001	2	5
BLOOD_Lymphoma	SPECC1 →	+4.340	+2.616	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ODR4 by Regulation of macrophage fusion activity — LARGE_INTESTINE

Explore this box plot interactively →