tRNA thio-modification

Across TCGA patient cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the RNA expression of multiple genes, with the READ cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTU1, SNRPB, and RUVBL2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA thio-modification activity versus CTU1 in READ (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CTU1 →	+1.793	+0.105	<.001	<.001	3	33
KICH	SNRPB →	+0.914	+0.064	<.001	<.001	3	31
ACC	RUVBL2 →	+0.707	+0.036	.003	.001	2	32
TGCT	EXOSC5 →	+0.976	+0.049	<.001	<.001	3	31
READ	ZNF579 →	+1.024	+0.084	<.001	<.001	3	29
SCLC	PRPF31 →	+0.586	+0.116	<.001	<.001	2	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034227 vs CTU1 — READ

Explore this scatter interactively →