tRNA thio-modification

Across TCGA patient cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM28, CSE1L, and RUVBL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA thio-modification activity versus RBM28 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBM28 →	+0.353	+0.068	<.001	<.001	3	7
BRCA	CSE1L →	+0.305	+0.045	.002	.003	3	6
LSCC	RUVBL2 →	+0.210	+0.068	<.001	<.001	3	6
BRCA	WDR75 →	+0.320	+0.036	<.001	<.001	3	6
LUAD	LIG1 →	+0.382	+0.045	<.001	.001	3	6
BRCA	REXO4 →	+0.419	+0.043	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034227 vs RBM28 — LSCC

Explore this scatter interactively →