tRNA thio-modification

Across TCGA patient cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELOVL7, UBE2L6, and YBX1P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA thio-modification activity versus ELOVL7 in BRCA (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ELOVL7 →	-0.571	-0.099	.003	.004	3	4
LSCC	UBE2L6 →	-0.619	-0.150	.002	.008	3	3
LSCC	YBX1P3 →	+0.445	+0.191	.002	.007	3	3
BRCA	EEF1A2 →	+1.506	+0.127	.003	.003	2	4
COAD	ANK1 →	-0.452	-0.843	.001	<.001	3	3
UCEC	H4C12 →	+0.395	+0.141	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034227 vs ELOVL7 — BRCA

Explore this scatter interactively →