tRNA thio-modification

Across TCGA patient cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLTM_S590, THOC6, and CHAMP1_S275, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA thio-modification activity versus SLTM_S590 in CCRCC (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLTM_S590 →	-0.847	-0.198	<.001	<.001	3	3
COAD	THOC6 →	+0.159	+0.797	<.001	<.001	3	3
CCRCC	CHAMP1_S275 →	-1.884	-0.354	<.001	<.001	3	3
CCRCC	EXOC3L2_S79 →	-0.727	-0.189	<.001	<.001	3	3
CCRCC	HECTD1_S357 →	-1.832	-0.322	<.001	<.001	3	3
CCRCC	KIF1C_S1033 →	-1.241	-0.209	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034227 vs SLTM_S590 — CCRCC

Explore this scatter interactively →