tRNA thio-modification

Across TCGA cell cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTU1, MOCS3, and URM1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTU1 grouped by tRNA thio-modification-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTU1 →	-0.354	-1.684	<.001	<.001	3	12
LUNG_SCLC	MOCS3 →	-0.255	-0.928	<.001	.006	3	8
PANCREAS	URM1 →	-0.455	-2.322	.001	<.001	3	8
LUNG_NSCLC_LUSC	AHR →	+0.321	+1.723	.001	<.001	3	5
STOMACH	PGAP2 →	-0.152	-0.274	.003	.007	2	5
LARGE_INTESTINE	APOE →	-0.337	-1.180	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTU1 by tRNA thio-modification activity — BLOOD_Leukemia

Explore this box plot interactively →