tRNA thio-modification

Across TCGA cell cohorts, RNA activity of the tRNA thio-modification pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, MPLKIP, and PPA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA1 grouped by tRNA thio-modification-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABCA1 →	-3.210	-1.438	<.001	.009	3	4
BLOOD_Myeloma	MPLKIP →	-1.539	-2.154	.002	<.001	3	4
CNS	PPA2 →	-0.498	-1.112	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ZAP70 →	+0.209	+1.132	.009	<.001	3	3
KIDNEY	C4orf3 →	+1.496	+1.315	<.001	.008	3	3
KIDNEY	ZNF581 →	+0.553	+1.477	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA1 by tRNA thio-modification activity — SOFT_TISSUE

Explore this box plot interactively →