Carbohydrate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Carbohydrate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, MSRB3, and PLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate transmembrane transport activity versus LMOD1 in OV (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LMOD1 →	+0.837	+0.569	.005	.002	3	5
HNSC	MSRB3 →	+0.688	+0.798	<.001	<.001	3	5
UCEC	PLN →	+1.303	+0.479	<.001	.001	3	5
HNSC	ZEB1 →	+0.561	+0.763	.001	<.001	3	4
HNSC	ZNF385D →	+0.744	+0.853	<.001	<.001	3	4
HNSC	ABCA9 →	+1.087	+0.742	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034219 vs LMOD1 — OV

Explore this scatter interactively →