Protein hexamerization

Across TCGA patient cohorts, RNA activity of the Protein hexamerization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP4, STAM2, and DDX27, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein hexamerization activity versus UTP4 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP4 →	+0.343	+0.035	.003	.004	3	8
CCRCC	STAM2 →	-0.128	-0.031	.001	.005	3	7
LSCC	DDX27 →	+0.445	+0.061	<.001	<.001	3	7
UCEC	NOL11 →	+0.405	+0.081	<.001	<.001	3	7
BRCA	UTP15 →	+0.241	+0.031	.002	.004	3	7
LSCC	PDCD11 →	+0.319	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034214 vs UTP4 — BRCA

Explore this scatter interactively →