Protein hexamerization

Across TCGA patient cohorts, RNA activity of the Protein hexamerization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGST2, ITGA7, and MIR29B2CHG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein hexamerization activity versus MGST2 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MGST2 →	+0.296	+0.114	.009	.006	3	4
HNSC	ITGA7 →	-0.758	-0.146	.003	.006	3	4
HNSC	MIR29B2CHG →	-0.458	-0.116	<.001	.006	3	4
UCEC	PDE3B →	-0.630	-0.131	.003	.009	3	4
UCEC	AMY2B →	-0.497	-0.098	.008	.006	3	4
BRCA	ARRB1 →	-0.659	-0.590	.007	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034214 vs MGST2 — LUAD

Explore this scatter interactively →