Protein hexamerization

Across TCGA cell cohorts, RNA activity of the Protein hexamerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35C1, MAPKAPK2, and UMAD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35C1 grouped by Protein hexamerization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC35C1 →	-0.847	-0.515	.008	.003	3	6
CNS	MAPKAPK2 →	-0.736	-0.804	.001	.006	3	4
SOFT_TISSUE	UMAD1 →	-0.824	-0.370	.006	<.001	2	5
CNS	UNC5CL →	+0.301	+0.546	.002	.006	3	3
CNS	CECR2 →	+1.069	+0.863	.001	<.001	3	3
OESOPHAGUS	BCL3 →	-1.226	-0.278	.009	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35C1 by Protein hexamerization activity — LUNG_SCLC

Explore this box plot interactively →