Positive regulation of toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 9 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEL, CDH9, and CD86, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 9 signaling pathway activity versus CEL in HNSC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CEL →	-0.940	-0.464	<.001	<.001	3	4
GBM	CDH9 →	+0.774	+1.024	.001	<.001	3	3
PDAC	CD86 →	+0.341	+0.718	.007	<.001	3	3
HNSC	AADAC →	-1.115	-0.509	.001	<.001	3	3
GBM	EVI2A →	+0.482	+0.679	<.001	.002	3	3
HNSC	GGT6 →	-1.090	-0.585	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034165 vs CEL — HNSC

Explore this scatter interactively →