Positive regulation of toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 9 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3A1_S359, THOC5, and GBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 9 signaling pathway activity versus SF3A1_S359 in HNSC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SF3A1_S359 →	-0.221	-0.430	<.001	<.001	3	4
GBM	THOC5 →	-0.212	-0.783	<.001	<.001	3	4
HNSC	GBP2 →	+0.494	+0.574	.003	.001	3	3
BRCA	IFIH1_S301 →	+0.791	+0.750	<.001	<.001	2	4
OV	NELFE_S115 →	-1.283	-0.225	<.001	<.001	3	3
OV	NEURL4_S502 →	+0.599	+0.168	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034165 vs SF3A1_S359 — HNSC

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