Regulation of toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 9 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MX2, IFI44, and MX1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 9 signaling pathway activity versus MX2 in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MX2 →	+0.894	+0.077	<.001	<.001	3	8
LSCC	IFI44 →	+0.852	+0.064	.001	.001	3	7
GBM	MX1 →	+1.061	+0.062	<.001	<.001	3	7
GBM	APOL2 →	+0.452	+0.057	<.001	.004	3	7
OV	AKAP13_S2563 →	+0.702	+0.058	<.001	<.001	3	6
LSCC	XAF1 →	+0.492	+0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034163 vs MX2 — GBM

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