Regulation of toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 9 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC63, GREM1, and GCATP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 9 signaling pathway activity versus LRRC63 in GBM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRC63 →	+0.595	+0.932	.002	<.001	3	4
LSCC	GREM1 →	+0.711	+0.582	.007	.002	3	4
BRCA	GCATP1 →	-0.193	-0.583	.009	<.001	3	4
UCEC	LINC01693 →	+0.618	+0.468	.001	.003	3	3
LUAD	SAMD9L →	+0.557	+0.452	<.001	.002	3	3
GBM	KCTD4 →	+0.564	+0.980	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034163 vs LRRC63 — GBM

Explore this scatter interactively →