Toll-like receptor 8 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 8 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK3, SF3B6, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYRK3 grouped by Toll-like receptor 8 signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DYRK3 →	+2.920	+2.246	<.001	<.001	2	5
STOMACH	SF3B6 →	+0.875	+1.337	.001	.007	3	4
LARGE_INTESTINE	IKBIP →	+1.072	+0.906	<.001	.001	3	4
KIDNEY	ANLN →	+1.718	+1.318	<.001	.004	3	3
URINARY_TRACT	NAT9 →	+0.708	+1.438	.003	.005	3	3
URINARY_TRACT	MAPK8IP1 →	+2.199	+2.195	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYRK3 by Toll-like receptor 8 signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →