Toll-like receptor 8 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 8 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNL3, PLCD4, and ARHGAP42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNL3 grouped by Toll-like receptor 8 signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GNL3 →	-0.181	-0.137	.003	.004	3	5
LARGE_INTESTINE	PLCD4 →	-0.320	-0.200	<.001	.004	3	4
OVARY	ARHGAP42 →	+0.326	+1.803	.002	.002	3	4
SOFT_TISSUE	GNRHR →	+0.251	+1.516	.006	.002	3	3
BLOOD_Leukemia	RPS13 →	+0.387	+0.282	.002	.002	3	3
BLOOD_Leukemia	PRMT8 →	+0.180	+0.141	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNL3 by Toll-like receptor 8 signaling pathway activity — SKIN

Explore this box plot interactively →