Regulation of toll-like receptor 7 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 7 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OAS2, TAP1, and GBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 7 signaling pathway activity versus OAS2 in LSCC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	OAS2 →	+0.860	+0.129	<.001	<.001	3	10
LSCC	TAP1 →	+0.623	+0.133	<.001	<.001	3	10
UCEC	GBP1 →	+0.817	+0.097	<.001	<.001	3	10
HNSC	IFIT2 →	+0.854	+0.095	<.001	<.001	3	9
UCEC	MX2 →	+0.838	+0.142	<.001	<.001	3	9
HNSC	PARP12 →	+0.309	+0.083	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034155 vs OAS2 — LSCC

Explore this scatter interactively →