Positive regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAL, CARD16, and DEF6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 4 signaling pathway activity versus ITGAL in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGAL →	+0.515	+0.041	<.001	<.001	3	10
UCEC	CARD16 →	+0.498	+0.072	.002	.003	3	9
UCEC	DEF6 →	+0.468	+0.086	.001	.001	3	9
HNSC	FNBP1 →	+0.337	+0.074	.003	.001	3	9
UCEC	WAS →	+0.516	+0.061	<.001	.005	3	9
UCEC	FYB1 →	+0.749	+0.079	<.001	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034145 vs ITGAL — BRCA

Explore this scatter interactively →