Positive regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUD23, AKR7A3, and ANGPTL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 4 signaling pathway activity versus BUD23 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BUD23 →	-0.358	-0.740	<.001	.002	3	4
HNSC	AKR7A3 →	-0.843	-1.087	<.001	<.001	3	4
COAD	ANGPTL4 →	+0.606	+0.379	.004	.005	3	3
UCEC	RMND5A →	-0.199	-0.224	.008	.006	3	3
UCEC	NAPEPLD →	-0.468	-0.232	.001	.004	3	3
UCEC	ARMC10 →	-0.303	-0.267	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034145 vs BUD23 — LSCC

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