Positive regulation of toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF195, NDST3, and ASPHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF195 grouped by Positive regulation of toll-like receptor 4 signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF195 →	-0.677	-1.332	.002	.001	3	3
BONE	NDST3 →	+1.354	+1.675	.003	.001	3	3
BONE	ASPHD1 →	-2.790	-1.558	.002	.002	2	4
LARGE_INTESTINE	MFGE8 →	-1.909	-1.107	.005	.003	3	3
LARGE_INTESTINE	RFESD →	-0.720	-0.932	.003	.004	3	3
LARGE_INTESTINE	PICALM →	-0.907	-1.192	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF195 by Positive regulation of toll-like receptor 4 signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →