Positive regulation of toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSORS1C1, AHNAK, and UBA7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 4 signaling pathway activity versus PSORS1C1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PSORS1C1 →	-1.615	-0.321	.004	.003	3	6
BLOOD_Leukemia	AHNAK →	-1.864	-0.163	.007	.002	3	5
LARGE_INTESTINE	UBA7 →	-1.164	-0.392	.007	.007	3	5
BLOOD_Myeloma	THEMIS2 →	-3.476	-0.208	<.001	.004	3	5
BLOOD_Leukemia	HMGB1 →	+0.962	+0.220	<.001	<.001	3	5
BLOOD_Leukemia	IL13RA1 →	-1.632	-0.145	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034145 vs PSORS1C1 — UPPER_AERODIGESTIVE_TRACT

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