Negative regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LUC7L3, RRP1B, and HPF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor 4 signaling pathway activity versus LUC7L3 in OV (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LUC7L3 →	-0.200	-0.057	<.001	<.001	3	6
GBM	RRP1B →	-0.281	-0.050	<.001	.005	3	6
COAD	HPF1 →	-0.326	-0.050	<.001	<.001	3	5
LUAD	RRP36_S73 →	-0.552	-0.052	.007	.009	3	5
GBM	SART1 →	-0.237	-0.075	.001	<.001	3	5
GBM	SF3B2 →	-0.204	-0.065	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034144 vs LUC7L3 — OV

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