Negative regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2IP, ITGA7, and ZFPM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor 4 signaling pathway activity versus DAB2IP in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DAB2IP →	+0.541	+0.948	<.001	<.001	3	4
UCEC	ITGA7 →	-0.713	-0.770	.004	.003	3	3
UCEC	ZFPM2 →	-0.771	-0.795	.004	<.001	3	3
GBM	SPTLC2 →	+0.433	+0.773	.001	<.001	3	3
GBM	DENND6A →	+0.255	+0.651	.003	.004	3	3
GBM	MTFR1 →	+0.201	+0.551	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034144 vs DAB2IP — HNSC

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