Regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN1, SH2D1A, and ZAP70, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 4 signaling pathway activity versus SEPTIN1 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN1 →	+0.693	+0.073	<.001	<.001	3	9
LSCC	SH2D1A →	+0.589	+0.080	.002	<.001	3	8
OV	ZAP70 →	+0.526	+0.029	<.001	.004	3	8
OV	ANKRD44 →	+0.563	+0.031	<.001	.002	3	8
OV	LPXN →	+0.588	+0.030	.001	.004	3	8
OV	GIMAP7 →	+0.626	+0.030	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034143 vs SEPTIN1 — LSCC

Explore this scatter interactively →