Regulation of toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, CHCHD5, and DDIAS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 4 signaling pathway activity versus TIMELESS in UCEC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMELESS →	-0.835	-0.463	.002	.006	3	4
UCEC	CHCHD5 →	-0.731	-0.614	.001	.001	3	4
UCEC	DDIAS →	-0.525	-0.411	.008	.008	3	4
LSCC	PARPBP →	-0.544	-0.311	<.001	.009	3	4
PDAC	ASS1P2 →	-0.215	-0.687	.004	<.001	3	4
OV	ABI1 →	+0.243	+0.085	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034143 vs TIMELESS — UCEC

Explore this scatter interactively →